Reactome | NDUFA1 [mitochondrial inner membrane]

NDUFA1 [mitochondrial inner membrane]

Stable Identifier

R-RNO-60212

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

mitochondrial inner membrane

Synonyms

A0A0G2K9V1

Locations in the PathwayBrowser

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Metabolism (Rattus norvegicus)

- Aerobic respiration and respiratory electron transport (Rattus norvegicus)
  - Respiratory electron transport (Rattus norvegicus)
    - Complex I biogenesis (Rattus norvegicus)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
      - ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Rattus norvegicus)
      - Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFA1 [mitochondrial inner membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2K9V1

Reference Genes

BioGPS Gene:313450 Rnf113a1

ENSEMBL:ENSRNOG00000040005

ENSEMBL:ENSRNOG00000052226

ENSEMBL:ENSRNOG00000071176

KEGG:rno:24631 Rnf113a1

KEGG:rno:313450 Rnf113a1

Monarch:313450 Rnf113a1

NCBI Gene:313450 Rnf113a1

UCSC:A0A0G2K9V1

Reference Transcript

RefSeq:NM_001014791.2 Rnf113a1

Other Identifiers

10936285

10940513

1370142_at

1374906_at

17875466

17881961

17881962

313450

5626997

5902629

6254533

6340824

6579295

6728506

A_44_P302944

A_44_P333209

A_64_P070155

GE1164373

GE1256119

GO:0003677

GO:0005634

GO:0005739

GO:0005743

GO:0016020

GO:0031966

GO:0045271

GO:0046872

ILMN_1360461

PH_rn_0000081

S82627_s_at

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)

Inferred From

NDUFA1 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_001014791.1

ENSEMBL

ENSRNOT00000081761, ENSRNOG00000066548, ENSRNOP00000075141

RGD

1359693

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