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NDUFA1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60212
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase MWFE subunit , Complex I-MWFE, CI-MWFE
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15239 NDUFA1
Gene Names
NDUFA1
Chain
chain:1-70
Reference Genes
BioGPS Gene:4694 NDUFA1
COSMIC (genes):NDUFA1 NDUFA1
CTD Gene:4694 NDUFA1
dbSNP Gene:4694 NDUFA1
ENSEMBL:ENSG00000125356 NDUFA1
HGNC:7683 NDUFA1
KEGG Gene (Homo sapiens):4694 NDUFA1
Monarch:4694 NDUFA1
NCBI Gene:4694 NDUFA1
OMIM:300078 NDUFA1
Reference Transcript
RefSeq:NM_004541.3 NDUFA1
Other Identifiers
0004060010
11723291_a_at
11753867_a_at
11756125_x_at
17106604
202298_PM_at
202298_at
36169_at
3988989
3988990
3988991
3988994
4694
8169659
A_23_P159833
A_24_P348649
GE61801
GO:0003674
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005743
GO:0005747
GO:0006091
GO:0006120
GO:0006810
GO:0007005
GO:0008137
GO:0008150
GO:0009058
GO:0009060
GO:0016020
GO:0016021
GO:0016491
GO:0022607
GO:0022857
GO:0031966
GO:0032981
GO:0032991
GO:0034641
GO:0042776
GO:0043226
GO:0044281
GO:0055085
GO:0065003
GO:0070469
HMNXSV003032683
ILMN_1784286
PH_hs_0035451
TC0X000589.hg
g13699820_3p_at
Participates
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ndufa1 [mitochondrial inner membrane]
(Danio rerio)
ndufa1 [mitochondrial inner membrane]
(Xenopus tropicalis)
ND-MWFE [mitochondrial inner membrane]
(Drosophila melanogaster)
Ghost homologue of NDUFA1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
NDUFA1 [mitochondrial inner membrane]
(Bos taurus)
NDUFA1 [mitochondrial inner membrane]
(Canis familiaris)
NDUFA1 [mitochondrial inner membrane]
(Gallus gallus)
NDUFA1 [mitochondrial inner membrane]
(Sus scrofa)
Ndufa1 [mitochondrial inner membrane]
(Mus musculus)
Ndufa1 [mitochondrial inner membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_004532.1
OpenTargets
ENSG00000125356
GeneCards
O15239
HPA
ENSG00000125356-NDUFA1
Ensembl
ENST00000371437
,
ENSG00000125356
,
ENSP00000360492
PRO
O15239
Pharos - Targets
O15239
Orphanet
16872
HMDB Protein
HMDBP00127
PDB
5XTI
,
5XTD
,
5XTH
,
5XTC
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