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NDUFA1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60212
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase MWFE subunit , Complex I-MWFE, CI-MWFE
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15239 NDUFA1
Gene Names
NDUFA1
Chain
chain:1-70
Reference Genes
BioGPS Gene:4694 NDUFA1
COSMIC (genes):NDUFA1 NDUFA1
CTD Gene:4694 NDUFA1
dbSNP Gene:4694 NDUFA1
ENSEMBL:ENSG00000125356 NDUFA1
HGNC:7683 NDUFA1
KEGG:hsa:4694 NDUFA1
Monarch:4694 NDUFA1
NCBI Gene:4694 NDUFA1
OMIM:300078 NDUFA1
UCSC:O15239 NDUFA1
Reference Transcript
RefSeq:NM_004541.4 NDUFA1
Other Identifiers
11723291_a_at
11753867_a_at
11756125_x_at
17106604
202298_PM_at
202298_at
36169_at
3988989
3988990
3988991
3988994
4694
8169659
A_23_P159833
A_24_P348649
GE61801
GO:0003824
GO:0005215
GO:0005739
GO:0005743
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0016491
GO:0031966
GO:0042776
GO:0043226
GO:0045271
GO:0055085
GO:0055086
GO:1901135
GO:1902600
HMNXSV003032683
ILMN_1784286
PH_hs_0035451
TC0X000589.hg
g13699820_3p_at
Participates
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
LOC481033 [mitochondrial inner membrane]
(Canis familiaris)
ndufa1 [mitochondrial inner membrane]
(Danio rerio)
ND-MWFE [mitochondrial inner membrane]
(Drosophila melanogaster)
Ghost homologue of NDUFA1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Ghost homologue of NDUFA1 [mitochondrial inner membrane]
(Rattus norvegicus)
Ghost homologue of NDUFA1 [mitochondrial inner membrane]
(Xenopus tropicalis)
NDUFA1 [mitochondrial inner membrane]
(Bos taurus)
NDUFA1 [mitochondrial inner membrane]
(Gallus gallus)
NDUFA1 [mitochondrial inner membrane]
(Sus scrofa)
Ndufa1 [mitochondrial inner membrane]
(Mus musculus)
Cross References
RefSeq
NP_004532.1
ENSEMBL
ENSP00000360492
,
ENST00000371437
,
ENSG00000125356
OpenTargets
ENSG00000125356
GeneCards
NDUFA1
HPA
ENSG00000125356-NDUFA1
PRO
O15239
Pharos - Targets
O15239
GlyGen
O15239
Orphanet
NDUFA1
HMDB Protein
HMDBP00127
PDB
5XTI
,
5XTH
,
5XTC
,
5XTD
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
3
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