Reactome | MAPK1 [cytosol]

MAPK1 [cytosol]

Stable Identifier

R-RNO-59282

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P63086

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - L1CAM interactions (Rattus norvegicus)
      - Signal transduction by L1 (Rattus norvegicus)
        
        MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)
        
        p-S,T-MAP2K2:MAPK1 [cytosol] (Rattus norvegicus)
        
        MAPK1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P63086 Mapk1

Gene Names

Mapk1, Erk2, Mapk, Prkm1

Chain

initiator methionine:, chain:2-358

Reference Genes

BioGPS Gene:116590 Mapk1

ENSEMBL:ENSRNOG00000001849.8 Mapk1

ENSEMBL:ENSRNOG00055003901 Mapk1

ENSEMBL:ENSRNOG00060002574 Mapk1

ENSEMBL:ENSRNOG00065008439 Mapk1

KEGG Gene (Rattus norvegicus):116590 Mapk1

Monarch:116590 Mapk1

NCBI Gene:116590 Mapk1

Reference Transcript

Other Identifiers

10755803

116590

1369078_at

1375692_at

1391705_at

1398346_at

17670871

5777862

5931521

5958919

6066039

6094041

6119902

6145785

6198510

6295425

6332911

6381196

6551905

6637753

6663748

A_44_P1047933

A_44_P386374

A_44_P386375

GE1241879

GE13977

GE19178

GE21828

GO:0003824

GO:0004672

GO:0004707

GO:0005524

GO:0006468

GO:0016740

GO:0023052

GO:0036211

GO:0140096

ILMN_1349290

M64300_at

rc_AI103916_at

rc_AI229025_at

Participates

as a component of

as an input of

MAP2K2 binds MAPK1 (Rattus norvegicus)

as a candidate of

MAPK3,(MAPK1) [cytosol] (Rattus norvegicus)

as a member of

MAPKs [cytosol] (Rattus norvegicus)

Other forms of this molecule

MAPK1 [ficolin-1-rich granule lumen]

MAPK1 [extracellular region]

MAPK1 [azurophil granule lumen]

Erk2 [cytosol]

p-T183,Y185-Mapk1 [nucleoplasm]

phospho-p-T185-MAPK1 [cytosol]

MAPK1 [nucleoplasm]

phospho-p-T185,Y187-MAPK1 [cytosol]

phospho-p-T185,Y187-MAPK1 [nucleoplasm]

Inferred From

MAPK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006248720.1, NP_446294.1, XP_008767070.1, XP_006248721.1

ZINC - Substances

MK01_RAT

Ensembl

ENSRNOP00000002533, ENSRNOT00000002533, ENSRNOG00000001849

ZINC target

P63086

PRO

P63086

RGD

70500

ZINC - Predictions - Purchasable

MK01_RAT

PDB

2ERK, 4S2Z, 5HD7, 6RFO, 6OT6, 6FMA, 4GVA, 4XP2, 6FQ7, 4S32, 3ERK, 3ZU7, 7UGB, 1GOL, 6FLE, 3ZUV, 2FYS, 6FJZ, 3QYZ, 6CPW, 4S33, 4XNE, 6OTS, 6FI6, 5KE0, 4XOY, 6FN5, 6FRP, 4ERK, 5HD4, 4S34, 4XOZ, 2Z7L, 4S30, 6FXV, 4XP0, 4GSB, 6OPK, 5U6I, 6FJ0, 4XRJ, 3O71, 6FI3, 6RFP, 4QYY, 4XRL, 6DCG, 2GPH, 4XP3, 5UMO, 4GT3, 3QYW, 3C9W, 6FLV, 4N4S, 4I5H, 3R63, 6FJB, 4S31, 6FR1

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q63155 Dcc	5	DCC [plasma membrane] (R-RNO-421662) phospho-Dcc [plasma membrane] (R-RNO-374552) Dcc [cytosol] (R-RNO-373629) Dcc [plasma membrane] (R-RNO-197560) Dcc [plasma membrane] (R-RNO-373627)	0.706	10
UniProt:Q8CDB0 MKNK2			0.527	2
UniProt:O08605	1	phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (R-MMU-947860)	0.527	2

Cite Us!