Reactome | phospho-p-T185,Y187-MAPK1 [cytosol]

phospho-p-T185,Y187-MAPK1 [cytosol]

Stable Identifier

R-RNO-109853

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P63086

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Prophase (Rattus norvegicus)
      - Golgi Cisternae Pericentriolar Stack Reorganization (Rattus norvegicus)
        
        MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)
        
        p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer [cytosol] (Rattus norvegicus)
        
        p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
        
        phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)

Programmed Cell Death (Rattus norvegicus)

- Apoptosis (Rattus norvegicus)
  - Intrinsic Pathway for Apoptosis (Rattus norvegicus)
    - Apoptotic factor-mediated response (Rattus norvegicus)
      - Cytochrome c-mediated apoptotic response (Rattus norvegicus)
        
        Formation of apoptosome (Rattus norvegicus)
        
        Regulation of the apoptosome activity (Rattus norvegicus)
        
        CASP9 is phosphorylated at T412 (Rattus norvegicus)
        
        p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
        
        p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
        
        phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P63086 Mapk1

Gene Names

Mapk1, Erk2, Mapk, Prkm1

Chain

initiator methionine:1, chain:2-358

Reference Genes

BioGPS Gene:116590 Mapk1

KEGG:rno:116590 Mapk1

Monarch:116590 Mapk1

NCBI Gene:116590 Mapk1

UCSC:P63086 Mapk1

Reference Transcript

Other Identifiers

10755803

116590

1369078_at

1375692_at

1391705_at

1398346_at

17670871

5777862

5931521

5958919

6066039

6094041

6119902

6145785

6198510

6295425

6332911

6381196

6551905

6637753

6663748

A_44_P1047933

A_44_P386374

A_44_P386375

GE1241879

GE13977

GE19178

GE21828

GO:0000165

GO:0001784

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006468

GO:0006974

GO:0007173

GO:0007507

GO:0008286

GO:0008353

GO:0009887

GO:0010759

GO:0014032

GO:0014044

GO:0015630

GO:0016301

GO:0016740

GO:0019858

GO:0019902

GO:0030154

GO:0030278

GO:0030641

GO:0030878

GO:0031143

GO:0031663

GO:0032206

GO:0032496

GO:0033598

GO:0034198

GO:0035094

GO:0036064

GO:0038127

GO:0038133

GO:0042473

GO:0042552

GO:0042802

GO:0043226

GO:0043330

GO:0045542

GO:0045596

GO:0048009

GO:0048538

GO:0048856

GO:0050852

GO:0050853

GO:0051403

GO:0055086

GO:0060020

GO:0060291

GO:0060324

GO:0060425

GO:0060440

GO:0060716

GO:0061308

GO:0061514

GO:0070371

GO:0070849

GO:0071356

GO:0120041

GO:0140096

GO:0150078

ILMN_1349290

M64300_at

rc_AI103916_at

rc_AI229025_at

Participates

as an input of

Phosphorylation of L1 by ERK (Rattus norvegicus)

as a component of

as an output of

Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)

as a member of

p-T,Y MAPKs [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-p-T185,Y187-MAPK1 [nucleoplasm]

MAPK1 [cytosol]

MAPK1 [nucleoplasm]

phospho-p-T185-MAPK1 [cytosol]

p-T183,Y185-Mapk1 [nucleoplasm]

Erk2 [cytosol]

MAPK1 [azurophil granule lumen]

MAPK1 [extracellular region]

MAPK1 [ficolin-1-rich granule lumen]

Inferred From

p-T185,Y187-MAPK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 185 (in Homo sapiens)

Coordinate

185

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 187 (in Homo sapiens)

Coordinate

187

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENSRNOP00000002533, ENSRNOG00000001849, ENSRNOT00000002533

IntEnz

2.7.11.24

ZINC - Substances

MK01_RAT

ZINC target

P63086

PRO

P63086

RGD

70500

ZINC - Predictions - Purchasable

MK01_RAT

PDB

8QR6, 6FXV, 6FJZ, 6FLV, 6FJ0, 4QYY, 2ERK, 4XNE, 4GVA, 4S2Z, 6FLE, 3R63, 8QR3, 5KE0, 6OT6, 6FR1, 6FMA, 5HD4, 4XOZ, 2GPH, 4XP3, 8RM2, 6OPK, 1GOL, 4S31, 4ERK, 8QRC, 5U6I, 4S32, 8QRB, 4XP0, 4GT3, 3C9W, 4XRL, 4N4S, 6FI6, 4GSB, 8RLX, 3ERK, 6FQ7, 8QR8, 7UGB, 6FI3, 6FN5, 8QR7, 8QR5, 2FYS, 8RQX, 4S34, 3ZU7, 8QR2, 8QR4, 8RQW, 3ZUV, 5HD7, 5UMO, 3QYZ, 3QYW, 4XOY, 6FRP, 8RQV, 4S30, 6CPW, 4S33, 4XP2, 8QRA, 6OTS, 6DCG, 8QR9, 6RFP, 6FJB, 4I5H, 8RMB, 4XRJ, 6RFO, 3O71, 2Z7L

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q63155 Dcc	5	DCC [plasma membrane] (R-RNO-421662) phospho-Dcc [plasma membrane] (R-RNO-374552) Dcc [cytosol] (R-RNO-373629) Dcc [plasma membrane] (R-RNO-197560) Dcc [plasma membrane] (R-RNO-373627)	0.706	10
UniProt:O08605	1	phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (R-MMU-947860)	0.527	2
UniProt:Q8CDB0 MKNK2			0.527	2

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