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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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Docs
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phospho-p-T185,Y187-MAPK1 [cytosol]
Stable Identifier
R-RNO-109853
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P63086
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
M Phase (Rattus norvegicus)
Mitotic Prophase (Rattus norvegicus)
Golgi Cisternae Pericentriolar Stack Reorganization (Rattus norvegicus)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)
p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
Constitutive phosphorylation by pERK1/2 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Rattus norvegicus)
MAPK-dependent phosphorylation of KARS (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAPK1-dependent phosphorylation of MITF-M (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
L1CAM interactions (Rattus norvegicus)
Recycling pathway of L1 (Rattus norvegicus)
Phosphorylation of L1 by ERK (Rattus norvegicus)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signal transduction by L1 (Rattus norvegicus)
MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by NODAL (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Thrombin signalling through proteinase activated receptors (PARs) (Rattus norvegicus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Growth hormone receptor signaling (Rattus norvegicus)
Lyn activates ERK (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
IFNG signaling activates MAPKs (Rattus norvegicus)
JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
JAK2-activated MAPKs phosphorylate YBX1 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Intrinsic Pathway for Apoptosis (Rattus norvegicus)
Apoptotic factor-mediated response (Rattus norvegicus)
Cytochrome c-mediated apoptotic response (Rattus norvegicus)
Formation of apoptosome (Rattus norvegicus)
Regulation of the apoptosome activity (Rattus norvegicus)
CASP9 is phosphorylated at T412 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAPKs phosphorylate PP2A (Rattus norvegicus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAPK1 (ERK2) activation (Rattus norvegicus)
Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
PEA15 binds MAPK monomers and dimers (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs dimerize (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Negative regulation of MAPK pathway (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Negative feedback regulation of MAPK pathway (Rattus norvegicus)
Activated MAPK phosphorylates RAF1 (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Activated MAPKs phosphorylate BRAF (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
PEA15 binds MAPK monomers and dimers (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Rattus norvegicus)
p-T,Y MAPK monomers and dimers [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs dimerize (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
G-protein mediated events (Rattus norvegicus)
PLC beta mediated events (Rattus norvegicus)
Ca-dependent events (Rattus norvegicus)
phospho-PLA2 pathway (Rattus norvegicus)
Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
Estrogen-stimulated signaling through PRKCZ (Rattus norvegicus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Negative regulation of FGFR2 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Negative regulation of FGFR3 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Negative regulation of FGFR4 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
Frs2-mediated activation (Rattus norvegicus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs dimerize (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate NADPH Oxidases (Rattus norvegicus)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by Activin (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-T,Y MAPK dimers [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P63086 Mapk1
Gene Names
Mapk1, Erk2, Mapk, Prkm1
Chain
initiator methionine:, chain:2-358
Reference Genes
BioGPS Gene:116590 Mapk1
ENSEMBL:ENSRNOG00000001849.8 Mapk1
ENSEMBL:ENSRNOG00055003901 Mapk1
ENSEMBL:ENSRNOG00060002574 Mapk1
ENSEMBL:ENSRNOG00065008439 Mapk1
KEGG Gene (Rattus norvegicus):116590 Mapk1
Monarch:116590 Mapk1
NCBI Gene:116590 Mapk1
Reference Transcript
RefSeq:NM_053842.2 Mapk1
RefSeq:XM_006248658.3 Mapk1
RefSeq:XM_008768848.2 Mapk1
RefSeq:XM_006248659.3 Mapk1
Other Identifiers
10755803
116590
1369078_at
1375692_at
1391705_at
1398346_at
17670871
5777862
5931521
5958919
6066039
6094041
6119902
6145785
6198510
6295425
6332911
6381196
6551905
6637753
6663748
A_44_P1047933
A_44_P386374
A_44_P386375
GE1241879
GE13977
GE19178
GE21828
GO:0003824
GO:0004672
GO:0004707
GO:0005524
GO:0006468
GO:0016740
GO:0023052
GO:0036211
GO:0140096
ILMN_1349290
M64300_at
rc_AI103916_at
rc_AI229025_at
Participates
as an input of
Phosphorylation of L1 by ERK (Rattus norvegicus)
as a component of
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Rattus norvegicus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Rattus norvegicus)
p-T185,Y187 MAPK1 dimer [cytosol] (Rattus norvegicus)
as an output of
Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)
as a member of
p-T,Y MAPKs [cytosol] (Rattus norvegicus)
Other forms of this molecule
MAPK1 [azurophil granule lumen]
MAPK1 [extracellular region]
MAPK1 [ficolin-1-rich granule lumen]
Erk2 [cytosol]
phospho-p-T185-MAPK1 [cytosol]
p-T183,Y185-Mapk1 [nucleoplasm]
MAPK1 [nucleoplasm]
MAPK1 [cytosol]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
p-T185,Y187-MAPK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_006248721.1
,
XP_006248720.1
,
XP_008767070.1
,
NP_446294.1
ZINC - Substances
MK01_RAT
ZINC target
P63086
Ensembl
ENSRNOG00000001849
,
ENSRNOT00000002533
,
ENSRNOP00000002533
PRO
P63086
ZINC - Predictions - Purchasable
MK01_RAT
RGD
70500
PDB
6FR1
,
3ZUV
,
4XRL
,
4I5H
,
6FJ0
,
5HD4
,
4XP2
,
3C9W
,
4GSB
,
1GOL
,
4GVA
,
6FI6
,
4XRJ
,
6RFP
,
5U6I
,
4N4S
,
6FXV
,
6DCG
,
4S33
,
5KE0
,
6FMA
,
6OTS
,
5HD7
,
3QYW
,
4XNE
,
4XOY
,
6FLV
,
3QYZ
,
2GPH
,
4QYY
,
3O71
,
3R63
,
6CPW
,
4XP0
,
2ERK
,
6OPK
,
6FJZ
,
7UGB
,
4S34
,
6OT6
,
2Z7L
,
6FLE
,
6FN5
,
2FYS
,
6RFO
,
4S32
,
6FRP
,
6FI3
,
4ERK
,
4S31
,
6FQ7
,
6FJB
,
4S30
,
3ZU7
,
4XOZ
,
3ERK
,
4XP3
,
4S2Z
,
5UMO
,
4GT3
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63155 Dcc
5
DCC [plasma membrane]
(R-RNO-421662)
phospho-Dcc [plasma membrane]
(R-RNO-374552)
Dcc [cytosol]
(R-RNO-373629)
Dcc [plasma membrane]
(R-RNO-197560)
Dcc [plasma membrane]
(R-RNO-373627)
0.706
10
UniProt:Q8CDB0 MKNK2
0.527
2
UniProt:O08605
1
phospho-p-T250,T255,T385,S437-MKNK1 [cytosol]
(R-MMU-947860)
0.527
2
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