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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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phospho-p-S400,T290-MAP3K8 [cytosol]
Stable Identifier
R-RNO-5684259
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q63562
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
MAP3K8 is phosphorylated (Rattus norvegicus)
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q63562 Map3k8
Gene Names
Map3k8, Tpl2
Chain
chain:1-467
Reference Genes
BioGPS Gene:116596 Map3k8
KEGG:rno:116596 Map3k8
Monarch:116596 Map3k8
NCBI Gene:116596 Map3k8
UCSC:Q63562 Map3k8
Reference Transcript
RefSeq:NM_053847.2 Map3k8
Participates
as an output of
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
as a component of
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S400-MAP3K8 [cytosol]
Tpl2 [cytosol]
Inferred From
p-S400,T290-MAP3K8 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 290 (in Homo sapiens)
Coordinate
290
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 400 (in Homo sapiens)
Coordinate
400
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_446299.2
PRO
Q63562
RGD
620969
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