Reactome | p-S400,T290-MAP3K8 [cytosol]

p-S400,T290-MAP3K8 [cytosol]

Stable Identifier

R-HSA-5684259

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S,T-TPL2, Cot, Cot/Tpl-2, Mitogen-activated protein kinase kinase kinase 8

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P41279 MAP3K8

Gene Names

MAP3K8, COT, ESTF

Chain

chain:1-467

Reference Genes

BioGPS Gene:1326 MAP3K8

COSMIC (genes):MAP3K8 MAP3K8

CTD Gene:1326 MAP3K8

dbSNP Gene:1326 MAP3K8

ENSEMBL:ENSG00000107968 MAP3K8

ENSEMBL_homo_sapiens_GENE:ENSG00000107968.10 MAP3K8

HGNC:6860 MAP3K8

KEGG Gene (Homo sapiens):1326 MAP3K8

Monarch:1326 MAP3K8

NCBI Gene:1326 MAP3K8

OMIM:191195 MAP3K8

UCSC:P41279 MAP3K8

Reference Transcript

Other Identifiers

11736217_at

11747602_a_at

1326

16703642

1891_at

205027_PM_s_at

205027_s_at

3240988

3240989

3240990

3240995

3240996

3240997

3240998

3241005

3241008

3241010

3241013

3241015

3241017

3241018

3241019

3241020

34770_at

69820_at

7926900

A_14_P133193

A_14_P201691

A_23_P23947

D14497_at

GE57079

GO:0000165

GO:0000166

GO:0000287

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006468

GO:0007049

GO:0007155

GO:0007165

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0031295

GO:0036211

GO:0046872

GO:0106310

GO:0140096

HMNXSV003014689

ILMN_1741159

PH_hs_0025239

TC10000211.hg

g4885146_3p_a_at

Participates

as a component of

as an output of

3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Homo sapiens)

Other forms of this molecule

p-S400-MAP3K8 [cytosol]

MAP3K8 [cytosol]

Inferred To

phospho-p-S400,T290-MAP3K8 [cytosol] (Mus musculus)

phospho-p-S400,T290-MAP3K8 [cytosol] (Rattus norvegicus)

phospho-p-S400,T290-MAP3K8 [cytosol] (Saccharomyces cerevisiae)

phospho-map3k8 [cytosol] (Xenopus tropicalis)

phospho-MAP3K8 [cytosol] (Bos taurus)

phospho-MAP3K8 [cytosol] (Canis familiaris)

phospho-MAP3K8 [cytosol] (Gallus gallus)

phospho-MAP3K8 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 290

Coordinate

290

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 400

Coordinate

400

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016871199.1, XP_016871197.1, NP_005195.2, NP_001307890.1, NP_001231063.1, XP_016871198.1, XP_016871196.1

ZINC - World Drugs

M3K8_HUMAN

Guide to Pharmacology - Targets

2083

OpenTargets

ENSG00000107968

ZINC - Substances

M3K8_HUMAN

ZINC target

P41279

ZINC - Biogenic

M3K8_HUMAN

PRO

P41279

PDB

4Y83, 4Y85, 5IU2

ZINC - Metabolites

M3K8_HUMAN

HPA

ENSG00000107968-MAP3K8

GeneCards

P41279

Ensembl

ENSP00000443610, ENSG00000107968, ENST00000375321, ENST00000263056, ENSP00000364470, ENSP00000263056, ENST00000542547

Pharos - Targets

P41279

ZINC - Predictions - Purchasable

M3K8_HUMAN

HMDB Protein

HMDBP08753

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.927	14
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.774	10
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.66	8
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.656	3
UniProt:Q00653 NFKB2	6	monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500) NFKB2(1-900) [cytosol] (R-HSA-2677931) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) p-7S-p100 [cytosol] (R-HSA-5607629) NFKB2(1-454) [cytosol] (R-HSA-168144) NFKB2(1-454) [nucleoplasm] (R-HSA-177674)	0.564	3