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Sharpin [cytosol]
Stable Identifier
R-RNO-5212666
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
SHARPIN, Q9EQL9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC binds CFLAR (Rattus norvegicus)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC binds OTULIN (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC:OTULIN [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC ubiquitinates CFLAR at K351, K353 (Rattus norvegicus)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC ubiquitinates RIPK1 at K627 (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
SPATA2 links CYLD to LUBAC (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
LUBAC [cytosol] (Rattus norvegicus)
Sharpin [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9EQL9 Sharpin
Gene Names
Sharpin
Chain
chain:1-381
Reference Genes
BioGPS Gene:81859 Sharpin
KEGG:rno:81859 Sharpin
Monarch:81859 Sharpin
NCBI Gene:81859 Sharpin
UCSC:Q9EQL9 Sharpin
Reference Transcript
RefSeq:XM_039079946.2 Sharpin
RefSeq:NM_031153.2 Sharpin
Other Identifiers
10904910
1368069_at
17838576
5639967
5745231
5794007
5998321
6059831
6113449
6197419
6214226
6324637
6344086
6613268
6745240
6746583
81859
A_44_P1011726
A_44_P189211
GE13461
GO:0005829
GO:0007005
GO:0007249
GO:0008544
GO:0010803
GO:0030262
GO:0030674
GO:0031424
GO:0031593
GO:0042742
GO:0043123
GO:0043124
GO:0048856
GO:0050728
GO:0060090
GO:0071797
GO:0097039
GO:0098542
GO:2000348
ILMN_1373042
PH_rn_0014908
rc_AA858478_at
Participates
as a component of
LUBAC [cytosol] (Rattus norvegicus)
Other forms of this molecule
Sharpin [cytosol]
Inferred From
SHARPIN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_112415.1
,
XP_038935874.1
ENSEMBL
ENSRNOT00000018031
,
ENSRNOP00000018032
,
ENSRNOG00000012812
PRO
Q9EQL9
RGD
631353
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9WV48 Shank1
2
Shank1 [cytosol]
(R-RNO-6794229)
Shank1 [cytosol]
(R-RNO-6794274)
0.543
7
UniProt:P31016 Dlg4
3
Dlg4 [plasma membrane]
(R-RNO-9612601)
Dlg4 [cytosol]
(R-RNO-6794248)
Dlg4 [endocytic vesicle membrane]
(R-RNO-416847)
0.463
2
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