Reactome | Phosphorylation of Neurofascin

Phosphorylation of Neurofascin

Stable Identifier

R-RNO-445080

Type

Reaction [transition]

Species

Rattus norvegicus

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

The highly conserved FIGQY motif in the cytoplasmic domain of neurofascin is phosphorylated by tyrosine kinases in response to external signals. Phosphorylation of the tyrosine in the FIGQY motif inhibits ankyrin binding.

Literature References

PubMed ID	Title	Journal	Year
9151675	Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin Garver, TD, Ren, Q, Tuvia, S, Bennett, V	J Cell Biol	1997
9371782	The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation Tuvia, S, Garver, TD, Bennett, V	Proc Natl Acad Sci U S A	1997

Participants

Input

Output

Catalyst Activity

protein tyrosine kinase activity of unidentified protein tyrosine kinase [cytosol]

Physical Entity

unidentified protein tyrosine kinase [cytosol] (Rattus norvegicus)

Activity

protein tyrosine kinase activity (GO:0004713)

Orthologous Events

Phosphorylation of Neurofascin (Homo sapiens)

Authored

Garapati, P V (2008-07-30)

Reviewed

Maness, PF (2010-02-16)

Created

Garapati, P V (2009-10-27)

Cite Us!