Reactome | GRM7 [plasma membrane]

GRM7 [plasma membrane]

Stable Identifier

R-RNO-420536

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P35400

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
      - Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)
        
        GRM1-8:L-Glu [plasma membrane] (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)
        
        GRM7 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P35400

Reference Genes

BioGPS Gene:81672

ENSEMBL:ENSRNOG00000005662

ENSEMBL:ENSRNOG00055007981

ENSEMBL:ENSRNOG00060014101

ENSEMBL:ENSRNOG00065012289

KEGG:rno:81672

Monarch:81672

NCBI Gene:81672

UCSC:P35400

Reference Transcript

RefSeq:NM_031040.1

Other Identifiers

10857643

1369781_at

17785885

5638590

5671203

5747381

5881130

5916196

6025952

6045148

6212786

6215130

6227522

6401026

6426321

6457224

6495973

6603696

6691880

6722251

81672

A_43_P12487

A_44_P445254

D16817_at

D16817_g_at

GE1291879

GO:0001642

GO:0004930

GO:0005886

GO:0005938

GO:0007154

GO:0007165

GO:0007186

GO:0007196

GO:0007268

GO:0007605

GO:0008066

GO:0010855

GO:0016020

GO:0023052

GO:0030425

GO:0043235

GO:0046983

GO:0050877

GO:0061564

GO:0070085

GO:0070905

ILMN_1376436

PH_rn_0012046

PH_rn_0019770

PH_rn_0023365

X96790_at

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Rattus norvegicus)

Inferred From

GRM7 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_112302.1

ENSEMBL

ENSRNOP00000053411, ENSRNOG00000005662, ENSRNOT00000056570

ZINC - Substances

GRM7_RAT

ZINC target

P35400

PRO

P35400

GlyGen

P35400

RGD

619857

ZINC - Predictions - Purchasable

GRM7_RAT

PDB

2E4Z

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9EP80 Pick1	3	Pick1 [plasma membrane] (R-RNO-8858476) PICK1 [plasma membrane] (R-RNO-416989) PICK1 [endocytic vesicle membrane] (R-RNO-417017)	0.737	9
UniProt:P63088 Ppp1cc	2	Serine/threonine protein phosphatase PP1-gamma catalytic subunit [cytosol] (R-RNO-163463) PPP1CC [cytosol] (R-RNO-163443)	0.508	4