Reactome | GRM7 [plasma membrane]

GRM7 [plasma membrane]

Stable Identifier

R-HSA-420536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Metabotropic glutamate receptor 7, GRM7_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - Metabotropic glutamate receptors bind glutamate (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14831 GRM7

Gene Names

GRM7, GPRC1G, MGLUR7

Chain

signal peptide:1-34, chain:35-915

Reference Genes

BioGPS Gene:2917 GRM7

COSMIC (genes):GRM7 GRM7

CTD Gene:2917 GRM7

dbSNP Gene:2917 GRM7

ENSEMBL:ENSG00000196277 GRM7

HGNC:4599 GRM7

KEGG Gene (Homo sapiens):2917 GRM7

Monarch:2917 GRM7

NCBI Gene:2917 GRM7

OMIM:604101 GRM7

UCSC:Q14831 GRM7

Reference Transcript

Other Identifiers

0002570408

0004200369

0006180056

11735499_a_at

11745581_a_at

207548_at

217008_s_at

2609068

2609069

2609070

2609071

2609120

2609135

2609136

2609149

2609158

2609160

2609178

2609194

2609195

2609196

2609203

2609207

2609209

2609210

2609213

2609214

2609222

2609223

2917

31585_at

72582_at

8077472

A_14_P106166

A_23_P22364

A_32_P165974

GE58238

GO:0001642

GO:0003674

GO:0004930

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005887

GO:0005938

GO:0006810

GO:0007165

GO:0007186

GO:0007196

GO:0007216

GO:0007267

GO:0007268

GO:0007605

GO:0008066

GO:0008150

GO:0010855

GO:0014050

GO:0016020

GO:0016021

GO:0030234

GO:0030424

GO:0030425

GO:0031279

GO:0032279

GO:0032991

GO:0043167

GO:0043198

GO:0043235

GO:0045211

GO:0048786

GO:0050877

GO:0050896

GO:0051966

GO:0070905

Hs.83407.1.S1_3p_a_at

ILMN_1696060

ILMN_1716680

ILMN_1779642

ILMN_1791500

PH_hs_0004763

U92458_at

g4504146_3p_at

Participant Of

hasMember

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane]

Inferred To

GRM7 [plasma membrane] (Bos taurus)

GRM7 [plasma membrane] (Canis familiaris)

GRM7 [plasma membrane] (Gallus gallus)

GRM7 [plasma membrane] (Sus scrofa)

grm7 [plasma membrane] (Xenopus tropicalis)

mgl-3 [plasma membrane] (Caenorhabditis elegans)

Grm7 [plasma membrane] (Mus musculus)

Grm7 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000835.1, NP_870989.1

OpenTargets

ENSG00000196277

ZINC - Substances

GRM7_HUMAN

GeneCards

Q14831

HPA

ENSG00000196277-GRM7

ZINC target

Q14831

Ensembl

ENST00000486284, ENSP00000350348, ENST00000389336, ENST00000467425, ENST00000357716, ENSG00000196277, ENST00000389335, ENSP00000373986, ENSP00000373987, ENSP00000419835, ENSP00000417536

PRO

Q14831

ZINC - Predictions - Purchasable

GRM7_HUMAN

PDB

3MQ4, 5C5C

HMDB Protein

HMDBP10862

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