Reactome | GRM7 [plasma membrane]

GRM7 [plasma membrane]

Stable Identifier

R-HSA-420536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Metabotropic glutamate receptor 7, GRM7_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - Metabotropic glutamate receptors bind glutamate (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)
        
        GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM7 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14831 GRM7

Gene Names

GRM7, GPRC1G, MGLUR7

Chain

signal peptide:1-34, chain:35-915

Reference Genes

BioGPS Gene:2917 GRM7

COSMIC (genes):GRM7 GRM7

CTD Gene:2917 GRM7

dbSNP Gene:2917 GRM7

ENSEMBL:ENSG00000196277 GRM7

HGNC:4599 GRM7

KEGG:hsa:2917 GRM7

Monarch:2917 GRM7

NCBI Gene:2917 GRM7

OMIM:604101 GRM7

UCSC:Q14831 GRM7

Reference Transcript

Other Identifiers

11735499_a_at

11745581_a_at

207548_PM_at

207548_at

217008_PM_s_at

217008_s_at

241049_PM_at

241049_at

2609056

2609068

2609069

2609070

2609071

2609074

2609075

2609082

2609094

2609120

2609134

2609135

2609136

2609149

2609150

2609156

2609158

2609160

2609173

2609174

2609178

2609183

2609190

2609194

2609195

2609196

2609197

2609198

2609199

2609200

2609201

2609202

2609203

2609207

2609209

2609210

2609212

2609213

2609214

2609215

2609221

2609222

2609223

2917

31585_at

53615_at

72582_at

8077472

A_14_P106166

A_14_P132385

A_23_P22364

A_32_P165974

GE58238

GO:0001642

GO:0004930

GO:0005509

GO:0005886

GO:0005938

GO:0007186

GO:0007193

GO:0007196

GO:0007216

GO:0007268

GO:0007605

GO:0008066

GO:0010855

GO:0014050

GO:0016020

GO:0016595

GO:0023052

GO:0030165

GO:0030424

GO:0030425

GO:0032279

GO:0043198

GO:0043235

GO:0045211

GO:0046983

GO:0048786

GO:0050877

GO:0051966

GO:0060089

GO:0061564

GO:0070085

GO:0070905

GO:0098772

HMNXSV003035096

Hs.59956.0.A1_3p_at

Hs.83407.1.S1_3p_a_at

ILMN_1696060

ILMN_1716680

ILMN_1791500

PH_hs_0004763

U92458_at

g4504146_3p_at

p25264

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)

Inferred To

GRM7 [plasma membrane] (Bos taurus)

GRM7 [plasma membrane] (Canis familiaris)

GRM7 [plasma membrane] (Gallus gallus)

GRM7 [plasma membrane] (Mus musculus)

GRM7 [plasma membrane] (Rattus norvegicus)

GRM7 [plasma membrane] (Sus scrofa)

grm7 [plasma membrane] (Xenopus tropicalis)

mgl-3 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_870989.1, NP_000835.1

Guide to Pharmacology - Targets

295

ENSEMBL

ENST00000389336, ENST00000357716, ENST00000486284, ENSP00000419835, ENSG00000196277, ENST00000389335, ENSP00000417536, ENSP00000350348, ENST00000467425, ENSP00000373987, ENSP00000373986

OpenTargets

ENSG00000196277

ZINC - Substances

GRM7_HUMAN

ZINC target

Q14831

PRO

Q14831

GlyGen

Q14831

PDB

7EPC, 7EPD, 3MQ4, 5C5C

GeneCards

GRM7

HPA

ENSG00000196277-GRM7

Pharos - Targets

Q14831

ZINC - Predictions - Purchasable

GRM7_HUMAN

HMDB Protein

HMDBP10862

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