Reactome | Faap100 [nucleoplasm]

Faap100 [nucleoplasm]

Stable Identifier

R-RNO-419545

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

FAAP100, A0A8I5ZNL4

Locations in the PathwayBrowser

Expand all

DNA Repair (Rattus norvegicus)

- Fanconi Anemia Pathway (Rattus norvegicus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - POLN binds ICL-DNA (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
  - Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap100 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
      - Faap100 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I5ZNL4

Gene Names

Faap100

Reference Genes

BioGPS Gene:303742 Faap100

ENSEMBL:ENSRNOG00000036699

KEGG:rno:303742 Faap100

Monarch:303742 Faap100

NCBI Gene:303742 Faap100

UCSC:A0A8I5ZNL4 Faap100

Reference Transcript

RefSeq:XM_039087819.2 Faap100

Other Identifiers

10749620

17663957

303742

5630939

5727771

5743644

5743798

5774845

6065416

6094324

6115413

6213010

6228344

6262587

6431523

6481156

6624610

6664183

6672897

6679927

6716015

A_44_P419966

A_64_P012129

GE1273403

GO:0000785

GO:0005654

GO:0005829

GO:0036297

GO:0043240

ILMN_1366318

PH_rn_0017128

Participates

as a component of

Other forms of this molecule

Faap100 [cytosol]

Inferred From

FAAP100 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_038943747.1

ENSEMBL

ENSRNOP00000079865, ENSRNOG00000036699, ENSRNOT00000103912

RGD

1306926

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