Reactome | Fbxl5 [cytosol]

Fbxl5 [cytosol]

Stable Identifier

R-RNO-391295

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

FBXL5, A0A0G2JTC9

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxl5 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JTC9

Gene Names

Fbxl5

Reference Genes

ENSEMBL:ENSRNOG00000005261

ENSEMBL:ENSRNOG00000005261.8 Fbxl5

Reference Transcript

RefSeq:XM_006251076.2 Fbxl5

Other Identifiers

10773148

1372776_at

17690381

305424

5627513

5691933

5715648

5755339

5930725

6109866

6294832

6322823

6359401

6401777

6449977

6454292

6542369

6627304

A_44_P458395

GE15880

GO:0005506

GO:0005515

GO:0006879

GO:0016567

GO:0019005

GO:0030163

GO:0031146

GO:0036211

GO:0045732

GO:0048471

GO:0055065

GO:0060586

ILMN_1368423

Participates

as an input of

CUL1, SKP1, FBXL5 bind (Rattus norvegicus)

as a component of

SKP1:CUL1:FBXL5 [cytosol] (Rattus norvegicus)

as a member of

F-box protein [cytosol] (Rattus norvegicus)

Inferred From

FBXL5 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006251138.1

Ensembl

ENSRNOG00000005261, ENSRNOP00000068659, ENSRNOT00000078326

RGD

1306887

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