Reactome | Prkag3 [cytosol]

Prkag3 [cytosol]

Stable Identifier

R-RNO-381839

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

PRKAG3, D4A7E4

Locations in the PathwayBrowser

Expand all

Autophagy (Rattus norvegicus)

- Macroautophagy (Rattus norvegicus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - ULK complex translocates to the ER (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - ULK1 phosphorylates Beclin-1 (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - p-AMPK:AMP binds the ULK complex (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - TP53 Regulates Metabolic Genes (Rattus norvegicus)
        
        SESN1,2,3 bind AMPK (Rattus norvegicus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK gamma [cytosol] (Rattus norvegicus)
        
        Prkag3 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A7E4

Gene Names

Prkag3

Reference Genes

ENSEMBL:ENSRNOG00000017248

KEGG:rno:301518 Prkag3

UCSC:D4A7E4 Prkag3

Other Identifiers

10928963

1394711_at

17865516

301518

5687555

5793335

5826156

5829827

5906489

6005484

6067138

6175197

6252902

6283430

6317483

6375010

6437489

6457024

6530968

6742797

A_44_P469088

A_44_P624098

A_64_P122263

GE1108648

GO:0003824

GO:0004679

GO:0005634

GO:0005737

GO:0005829

GO:0006110

GO:0006629

GO:0006631

GO:0006633

GO:0014873

GO:0016208

GO:0016740

GO:0019887

GO:0019901

GO:0031588

GO:0031669

GO:0042149

GO:0043609

GO:0045719

GO:0045722

GO:0140096

ILMN_1369558

ILMN_2040509

PH_rn_0008283

Participates

as a member of

AMPK gamma [cytosol] (Rattus norvegicus)

Other forms of this molecule

Prkag3 [endoplasmic reticulum lumen]

Prkag3 [nucleoplasm]

Inferred From

PRKAG3 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOT00000023365, ENSRNOG00000017248, ENSRNOP00000023365

RGD

1308698

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