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PRKAG3 [cytosol]
Stable Identifier
R-HSA-381839
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
AMPK gamma3, 5'-AMP-activated protein kinase subunit gamma-3, AAKG3_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Selective autophagy (Homo sapiens)
Lipophagy (Homo sapiens)
PRKAA2 phosphorylates PLINs (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Thr-180 of ULK1 is phosphorylated (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
ULK complex translocates to the ER (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
ULK1 phosphorylates Beclin-1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK:AMP binds the ULK complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
SESN1,2,3 bind AMPK (Homo sapiens)
SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
AMPK phosphorylates MAPT (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
CAMKK2 phosphorylates AMPK (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Phosphorylated AMPK binds AMP (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UGI9 PRKAG3
Gene Names
PRKAG3, AMPKG3
Chain
chain:1-489
Reference Genes
BioGPS Gene:53632 PRKAG3
COSMIC (genes):PRKAG3 PRKAG3
CTD Gene:53632 PRKAG3
dbSNP Gene:53632 PRKAG3
ENSEMBL:ENSG00000115592 PRKAG3
HGNC:9387 PRKAG3
KEGG:hsa:53632 PRKAG3
Monarch:53632 PRKAG3
NCBI Gene:53632 PRKAG3
OMIM:604976 PRKAG3
UCSC:Q9UGI9 PRKAG3
Reference Transcript
RefSeq:XM_017004343.1 PRKAG3
RefSeq:NM_017431.2 PRKAG3
Other Identifiers
11734256_a_at
11734257_at
11734258_a_at
11756834_a_at
16908449
223904_PM_at
223904_at
2599581
2599582
2599583
2599584
2599585
2599586
2599587
2599588
2599589
2599590
2599591
2599592
2599593
2599594
2599595
2599596
2599597
2599598
2599599
2599601
2599602
2599603
48307_at
53632
8058997
A_23_P28258
A_33_P3244843
GE55295
GO:0003824
GO:0004679
GO:0005515
GO:0005524
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005975
GO:0005978
GO:0006091
GO:0006096
GO:0006629
GO:0006633
GO:0014873
GO:0016208
GO:0016301
GO:0016740
GO:0019887
GO:0019901
GO:0031588
GO:0031669
GO:0035556
GO:0043226
GO:0055086
GO:0098772
GO:0140096
GO:1901135
HMNXSV003038134
ILMN_1716754
PH_hs_0025346
TC02002778.hg
g8215681_3p_at
Participates
as a member of
AMPK gamma [cytosol] (Homo sapiens)
Other forms of this molecule
PRKAG3 [nucleoplasm]
Inferred To
PRKAG3 [cytosol]
(Bos taurus)
PRKAG3 [cytosol]
(Canis familiaris)
PRKAG3 [cytosol]
(Gallus gallus)
PRKAG3 [cytosol]
(Saccharomyces cerevisiae)
PRKAG3 [cytosol]
(Schizosaccharomyces pombe)
PRKAG3 [cytosol]
(Sus scrofa)
aakg-4 [cytosol]
(Caenorhabditis elegans)
aakg-3 [cytosol]
(Caenorhabditis elegans)
Prkag3 [cytosol]
(Mus musculus)
Prkag3 [cytosol]
(Rattus norvegicus)
aakg-1 [cytosol]
(Caenorhabditis elegans)
prkag3 [cytosol]
(Xenopus tropicalis)
SNF4Agamma [cytosol]
(Drosophila melanogaster)
Homologues of PRKAG3 [cytosol]
(Caenorhabditis elegans)
prkag [cytosol]
(Dictyostelium discoideum)
aakg-2 [cytosol]
(Caenorhabditis elegans)
aakg-5 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016859832.1
,
NP_059127.2
Guide to Pharmacology - Targets
1547
ENSEMBL
ENSP00000436068
,
ENST00000529249
,
ENST00000439262
,
ENSP00000397133
OpenTargets
ENSG00000115592
HPA
ENSG00000115592-PRKAG3
PRO
Q9UGI9
Pharos - Targets
Q9UGI9
GlyGen
Q9UGI9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.643
4
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