PKA catalytic subunit translocates to the nucleus

Stable Identifier
R-RNO-379836
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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PKA catalytic subunit translocates to the nucleus
When cAMP level rises, the PKA catalytic subunit (C subunit) released from the holoenzyme enters the nucleus by passive diffusion whereas termination of signaling to the nucleus involves an active mechanism. In the nucleus, the C subunit binds to the heat-stable protein kinase inhibitor (PKI), and this binding not only inactivates the C subunit but also by conformational change unveils a nuclear export signal in PKI which leads to export of the C-PKI complex from the nucleus.
Literature References
PubMed ID Title Journal Year
8298196 Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion

Harootunian, AT, Adams, SR, Wen, W, Meinkoth, JL, Taylor, SS, Tsien, RY

Mol Biol Cell 1993
Participants
Input
Output
Orthologous Events
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Jassal, B  (2008-11-05)
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