Reactome | Clta [cytosol]

Clta [cytosol]

Stable Identifier

R-RNO-350828

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Clathrin light chain, P08081

Locations in the PathwayBrowser

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Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - clathrin:HSPA8:ADP [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Recruitment of AP-2 complex and clathrin (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        clathrin triskelion [cytosol] (Rattus norvegicus)
        
        Clathrin light chains [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
  - trans-Golgi Network Vesicle Budding (Rattus norvegicus)
    - Golgi Associated Vesicle Biogenesis (Rattus norvegicus)
      - trans-Golgi Network Coat Assembly (Rattus norvegicus)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)
        
        Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - trans-Golgi Network Vesicle Scission (Rattus norvegicus)
        
        Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
    - Lysosome Vesicle Biogenesis (Rattus norvegicus)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)
        
        Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)
        
        Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Rattus norvegicus)
        
        Clathrin Triskelion [cytosol] (Rattus norvegicus)
        
        Clta [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P08081 Clta

Gene Names

Clta

Chain

chain:1-248

Reference Genes

BioGPS Gene:83800 Clta

KEGG:rno:83800 Clta

Monarch:83800 Clta

NCBI Gene:83800 Clta

UCSC:P08081 Clta

Reference Transcript

Other Identifiers

10868634

1386875_a_at

17798394

5752603

5872459

6247754

6390925

6412831

6456627

6544504

6558696

6665902

6683455

83800

A_42_P703403

A_64_P144377

GE19669

GO:0005198

GO:0005764

GO:0005768

GO:0005794

GO:0006886

GO:0016192

GO:0030118

GO:0030130

GO:0030132

GO:0032050

GO:0048268

GO:0065003

GO:0071439

ILMN_1355725

M15882_at

M15882_g_at

PH_rn_0011405

Participates

as a component of

Clathrin Triskelion [cytosol] (Rattus norvegicus)

as a member of

Clathrin light chains [cytosol] (Rattus norvegicus)

Other forms of this molecule

Clta [trans-Golgi network membrane]

Clta [endolysosome membrane]

Clathrin light chain [clathrin-coated endocytic vesicle membrane]

Clta [clathrin-coated endocytic vesicle membrane]

Clta [lysosomal membrane]

Clta [plasma membrane]

Inferred From

Clathrin light chain [cytosol] (Homo sapiens)

CLTA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_114180.1, NP_001423521.1

ENSEMBL

ENSRNOT00000036366, ENSRNOG00000014635, ENSRNOP00000019737, ENSRNOP00000035138, ENSRNOT00000019737

PRO

P08081

RGD

70919

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