MeSec is hydrolysed to MeSeH by PXLP-K211-Cth

Stable Identifier
R-RNO-2408538
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MeSec is hydrolysed to MeSeH by PXLP-K211-Cth
In the cytosol of rat, methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (Cth) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. (Pinto et al. 2011, Suzuki et al. 2007).
Literature References
PubMed ID Title Journal Year
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Kurasaki, K, Suzuki, N

Biochim. Biophys. Acta 2007
20383543 Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds

Pinto, JT, Lee, JI, Sinha, R, MacEwan, ME, Cooper, AJ

Amino Acids 2011
Participants
Input
Output
Catalyst Activity

methylselenocysteine deselenhydrase activity of PXLP-K211-Cth tetramer [cytosol]

Physical Entity
PXLP-K211-Cth tetramer [cytosol] (Rattus norvegicus)
Activity
methylselenocysteine deselenhydrase activity (GO:0098607)
Orthologous Events
MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Hill, DP  (2025-02-25)
Created
Williams, MG  (2012-07-17)
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