SeCysta is hydrolysed to Sec by PXLP-K211-Cth

Stable Identifier
R-RNO-2408502
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SeCysta is hydrolysed to Sec by PXLP-K211-Cth
In rat cytosol, cystathionine gamma-lyase (Cth) homotetramer is involved in the hydrolysis of selenocystathionine (SeCysta) into selenocysteine (Sec), ammonia and 2-oxobutanoic acid by an alpha,gamma-elimination reaction (Esaki et al. 1981).
Literature References
PubMed ID Title Journal Year
6456763 Enzymatic synthesis of selenocysteine in rat liver

Esaki, N, Nakamura, T, Tanaka, H, Suzuki, T, Morino, Y, Soda, K

Biochemistry 1981
Participants
Input
Output
Catalyst Activity

selenocystathionine gamma-lyase activity of PXLP-K211-Cth tetramer [cytosol]

Physical Entity
PXLP-K211-Cth tetramer [cytosol] (Rattus norvegicus)
Activity
selenocystathionine gamma-lyase activity (GO:0098606)
Orthologous Events
SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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