Reactome | CLEC4E [plasma membrane]

CLEC4E [plasma membrane]

Stable Identifier

R-RNO-2130735

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Q67EQ1

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - C-type lectin receptors (CLRs) (Rattus norvegicus)
    - Dectin-2 family (Rattus norvegicus)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
      - PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
      - SYK autophosphorylates (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
      - SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Rattus norvegicus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Rattus norvegicus)
        
        CLEC4E [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q67EQ1

Reference Genes

BioGPS Gene:450223

ENSEMBL:ENSRNOG00000061394

ENSEMBL:ENSRNOG00055009490

ENSEMBL:ENSRNOG00060028204

ENSEMBL:ENSRNOG00065033485

KEGG:rno:450223

Monarch:450223

NCBI Gene:450223

UCSC:Q67EQ1

Reference Transcript

RefSeq:NM_001005897.2

Participates

as a component of

Inferred From

CLEC4E [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001005897.2

PRO

Q67EQ1

GlyGen

Q67EQ1

RGD

1359298

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