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CLEC4E [plasma membrane]
Stable Identifier
R-HSA-2130735
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-type lectin domain family 4 member E, CLC4E_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
Dectin-2 family (Homo sapiens)
CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)
CLEC4E:FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)
pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULY5 CLEC4E
Gene Names
CLEC4E, CLECSF9, MINCLE, UNQ218/PRO244
Chain
chain:1-219
Reference Genes
BioGPS Gene:26253 CLEC4E
COSMIC (genes):CLEC4E CLEC4E
CTD Gene:26253 CLEC4E
dbSNP Gene:26253 CLEC4E
ENSEMBL:ENSG00000166523 CLEC4E
HGNC:14555 CLEC4E
KEGG:hsa:26253 CLEC4E
Monarch:26253 CLEC4E
NCBI Gene:26253 CLEC4E
OMIM:609962 CLEC4E
UCSC:Q9ULY5 CLEC4E
Reference Transcript
RefSeq:NM_014358.3 CLEC4E
Other Identifiers
11736668_at
11745144_a_at
16760928
219859_PM_at
219859_at
222934_PM_s_at
222934_s_at
26253
3443184
3443185
3443186
3443187
3443188
3443189
3443190
3443191
3443192
3443193
3443194
3443195
3443196
3443197
3443198
3443199
75070_at
7960900
89128_at
A_24_P78531
A_33_P3318509
GE61106
GO:0001819
GO:0001891
GO:0002221
GO:0002292
GO:0002376
GO:0005509
GO:0005515
GO:0005886
GO:0006955
GO:0008289
GO:0009897
GO:0016020
GO:0030154
GO:0030246
GO:0030670
GO:0038023
GO:0038094
GO:0038187
GO:0042742
GO:0042995
GO:0045087
GO:0046872
GO:0051861
GO:0060089
GO:0061760
GO:0098542
HMNXSV003038982
ILMN_1771664
PH_hs_0012839
TC12001178.hg
g12653848_3p_a_at
g7657332_3p_at
g7657332_3p_x_at
Participates
as a component of
CLEC4E:FCER1G dimer [plasma membrane] (Homo sapiens)
CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Homo sapiens)
Inferred To
Homologues of CLEC4E [plasma membrane]
(Danio rerio)
illr4 [plasma membrane]
(Danio rerio)
LOC611538 [plasma membrane]
(Canis familiaris)
illr1 [plasma membrane]
(Danio rerio)
CLEC4E [plasma membrane]
(Bos taurus)
CLEC4E [plasma membrane]
(Danio rerio)
CLEC4E [plasma membrane]
(Mus musculus)
CLEC4E [plasma membrane]
(Rattus norvegicus)
CLEC4E [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_055173.1
Guide to Pharmacology - Targets
2929
ENSEMBL
ENSP00000299663
,
ENST00000299663
OpenTargets
ENSG00000166523
HPA
ENSG00000166523-CLEC4E
PRO
Q9ULY5
Pharos - Targets
Q9ULY5
GlyGen
Q9ULY5
PDB
3WH3
,
3WH2
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