Nrage activates Jnk1

Stable Identifier
R-RNO-205027
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nrage activates Jnk1
The NGF:p75:NRAGE complex promotes threonine and tyrosine phosphorylation, and activation of JNK, by an unknown mechanism.
Literature References
PubMed ID Title Journal Year
12376548 NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway

Xanthoudakis, S, Salehi, AH, Barker, PA

J Biol Chem 2002
Participants
Input
Output
Catalyst Activity

JUN kinase activity of NGF:p75NTR:Nrage [plasma membrane]

Physical Entity
NGF:p75NTR:Nrage [plasma membrane] (Rattus norvegicus)
Activity
JUN kinase activity (GO:0004705)
Orthologous Events
NRAGE activates JNK (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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