Reactome | Psma2 [nucleoplasm]

Psma2 [nucleoplasm]

Stable Identifier

R-RNO-174345

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

PSMA2, P17220

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G1/S DNA Damage Checkpoints (Rattus norvegicus)
    - p53-Independent G1/S DNA Damage Checkpoint (Rattus norvegicus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Rattus norvegicus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - Mitotic G1 phase and G1/S transition (Rattus norvegicus)
    - G1/S Transition (Rattus norvegicus)
      - Cyclin E associated events during G1/S transition (Rattus norvegicus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Rattus norvegicus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)
  - Regulation of mitotic cell cycle (Rattus norvegicus)
    - APC/C-mediated degradation of cell cycle proteins (Rattus norvegicus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Rattus norvegicus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Rattus norvegicus)
        
        Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)
  - S Phase (Rattus norvegicus)
    - Cyclin A:Cdk2-associated events at S phase entry (Rattus norvegicus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Rattus norvegicus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)

Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to chemical stress (Rattus norvegicus)
    - KEAP1-NFE2L2 pathway (Rattus norvegicus)
      - Nuclear events mediated by NFE2L2 (Rattus norvegicus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Rattus norvegicus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional regulation by RUNX3 (Rattus norvegicus)
      - Regulation of RUNX3 expression and activity (Rattus norvegicus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)
        
        26S proteasome [nucleoplasm] (Rattus norvegicus)
        
        20S core particle [nucleoplasm] (Rattus norvegicus)
        
        20S CP outer ring [nucleoplasm] (Rattus norvegicus)
        
        Psma2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P17220

Gene Names

Psma2

Reference Genes

BioGPS Gene:29669 Psma2

ENSEMBL:ENSRNOG00000049920

ENSEMBL:ENSRNOG00055011092

ENSEMBL:ENSRNOG00060014611

ENSEMBL:ENSRNOG00065018439

KEGG:rno:29669 Psma2

Monarch:29669 Psma2

NCBI Gene:29669 Psma2

UCSC:P17220 Psma2

Reference Transcript

RefSeq:NM_017279.2 Psma2

Other Identifiers

10798728

1398856_at

17719799

29669

5690966

5807963

5815596

5941483

6012728

6055143

6135150

6138060

6196777

6435845

6478474

6556266

6672911

6684882

6702656

E03358cds_at

E03358cds_g_at

GO:0000502

GO:0000932

GO:0005634

GO:0005737

GO:0005839

GO:0006511

GO:0009615

GO:0019773

GO:0030163

GO:0043161

GO:0043226

GO:0051603

ILMN_1371256

PH_rn_0005828

rc_AI170403_at

Participates

as a component of

20S CP outer ring [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

Psma2 [secretory granule lumen]

Psma2 [extracellular region]

Psma2 [ficolin-1-rich granule lumen]

Psma2 [cytosol]

Inferred From

PSMA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_058975.1

ENSEMBL

ENSRNOG00000049920, ENSRNOP00000066950, ENSRNOT00000073834

PRO

P17220

RGD

61842

PDB

6EPD, 6EPC, 6EPF, 6EPE, 6TU3

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