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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Pathway Diagrams
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FAQ
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Citing us
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Analyse gene list
Analyse gene expression
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IKBKB [cytosol]
Stable Identifier
R-RNO-168114
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q9QY78
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Rattus norvegicus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Activation of IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
PKR-mediated signaling (Rattus norvegicus)
IKK complex is activated by PKR (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Modulation of host responses by IFN-stimulated genes (Rattus norvegicus)
FKBP5 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
FKBP5:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated NF-kB activation (Rattus norvegicus)
Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
IKK complex recruitment mediated by RIP1 (Rattus norvegicus)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
IKBKB dimer [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
IKBKB dimer [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
IKBKB dimer [cytosol] (Rattus norvegicus)
IKBKB [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9QY78
Reference Genes
BioGPS Gene:84351
ENSEMBL:ENSRNOG00000019073
KEGG:rno:84351
Monarch:84351
NCBI Gene:84351
UCSC:Q9QY78
Reference Transcript
RefSeq:NM_053355.2
Participates
as a component of
FKBP5:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
IKBKB dimer [cytosol] (Rattus norvegicus)
CHUK:IKBKB:LRRC14 [cytosol] (Rattus norvegicus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Rattus norvegicus)
CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
as an input of
LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
Other forms of this molecule
phospho-p-S177,S181-IKBKB [cytosol]
Inferred From
IKBKB [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_445807.2
IntEnz
2.7.11.1
PRO
Q9QY78
RGD
621375
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O70377
4
phospho-Snap23 [phagocytic vesicle membrane]
(R-RNO-8863923)
Snap23 [tertiary granule membrane]
(R-RNO-6806141)
Snap23 [plasma membrane]
(R-RNO-376345)
Snap23 [specific granule membrane]
(R-RNO-6806157)
0.524
2
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