Reactome | LCK [cytosol]

LCK [cytosol]

Stable Identifier

R-RNO-167609

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Q01621

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - Negative regulation of the PI3K/AKT network (Rattus norvegicus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
        
        PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        Activator:PI3K [plasma membrane] (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Rattus norvegicus)
        
        FYN,LCK [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
      - Activator:PI3K [plasma membrane] (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Rattus norvegicus)
        
        FYN,LCK [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by SCF-KIT (Rattus norvegicus)
    - Dimerization of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - JAK2 binds to p-KIT (Rattus norvegicus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Phosphorylation and activation of VAV1 (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Phosphorylation of GAB2 by SFKs (Rattus norvegicus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Phosphorylation of JAK2 (Rattus norvegicus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Phosphorylation of SHP2 by SFKs (Rattus norvegicus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Phosphorylation of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Recruitment of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Regulation of KIT signaling (Rattus norvegicus)
      - Interaction of APS and p-KIT (Rattus norvegicus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - Phosphorylation of APS (Rattus norvegicus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - Recruitment of CBL to KIT (Rattus norvegicus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - SHP2 interacts with p-KIT (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
    - Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase cycle (Rattus norvegicus)
      - RHOH GTPase cycle (Rattus norvegicus)
        
        RHOH binds effectors at the plasma membrane (Rattus norvegicus)
        
        RHOH effectors [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Rattus norvegicus)
        
        RHOH effectors [cytosol] (Rattus norvegicus)
        
        LCK [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q01621

Reference Genes

BioGPS Gene:313050

ENSEMBL:ENSRNOG00000009705

KEGG:rno:313050

Monarch:313050

NCBI Gene:313050

UCSC:Q01621

Reference Transcript

Other Identifiers

10880033

1383320_at

17810834

313050

5628745

5645319

5676211

5779047

5902540

6005233

6079611

6150551

6238728

6314133

6330793

6367024

6448665

6674680

6730966

A_44_P511304

GE16791

GO:0000242

GO:0001772

GO:0001784

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0004722

GO:0005515

GO:0005524

GO:0005737

GO:0005886

GO:0005911

GO:0006468

GO:0006882

GO:0007166

GO:0009410

GO:0010628

GO:0016004

GO:0016740

GO:0016787

GO:0019901

GO:0019903

GO:0030154

GO:0030217

GO:0034116

GO:0035556

GO:0038094

GO:0042110

GO:0042169

GO:0042492

GO:0042608

GO:0042609

GO:0042610

GO:0042802

GO:0043274

GO:0043410

GO:0043548

GO:0045121

GO:0045588

GO:0045589

GO:0050852

GO:0050853

GO:0050856

GO:0050870

GO:0051117

GO:0051209

GO:0055085

GO:0098772

GO:0140096

GO:0160162

GO:1903039

GO:1990405

GO:2001244

ILMN_1356341

PH_rn_0001862

rc_AA800684_at

Participates

as a member of

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Rattus norvegicus)

as a component of

Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

phospho-p-Y394-LCK [plasma membrane]

phospho-p-Y505-LCK [plasma membrane]

phospho-p-Y394-LCK [cytosol]

Inferred From

LCK [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001402799.1, NP_001094179.1

ENSEMBL

ENSRNOP00000012936, ENSRNOT00000012936, ENSRNOG00000009705

PRO

Q01621

RGD

2994

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