Reactome | Trim28 in Trim28:ZNF74 autoSUMOylates with SUMO2

Trim28 in Trim28:ZNF74 autoSUMOylates with SUMO2

Stable Identifier

R-NUL-9842870

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

General

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Trim28 in Trim28:ZNF74 autoSUMOylates with SUMO2

Mouse Trim28 homodimer bound to human ZNF74 is SUMOylated on lysine residues 554, 575, 676, 750, 779, and 804 and the SUMOylation activity is stimulated by ZNF74 (Mascle et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17298944	Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain Mascle, XH, Germain-Desprez, D, Huynh, P, Estephan, P, Aubry, M	J. Biol. Chem.	2007

Participants

Input

Output

Catalyst Activity

SUMO ligase activity of Trim28:ZNF74 [nucleoplasm]

Physical Entity

Trim28:ZNF74 [nucleoplasm] (Homo sapiens)

Activity

SUMO ligase activity (GO:0061665)

Orthologous Events

TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2 (Homo sapiens)

Authored

May, B (2023-08-26)

Reviewed

Bourc'his, D (2024-05-14)

Fernandes, LP (2024-05-14)

Created

May, B (2023-08-29)

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