Reactome | TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2

TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2

Stable Identifier

R-HSA-9842868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2

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The PHD domain of TRIM28 (KAP1) is a SUMO E3 ligase that catalyzes the autoSUMOylation of lysines 554, 575, 676, 750, 779, and 804 in the bromodomain of TRIM28 (Ivanov et al. 2007, Yang et al. 2015). SUMOylated TRIM28 recruits SETDB1 and the NuRD repressor complex and stimulates the lysine methylation activity of SETDB1 (Ivanov et al. 2007). TRIM28 is a dimer (Fobti et al. 2019) that can form oligomers (inferred from the mouse homolog in Sun et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
26365490	Systematic identification of factors for provirus silencing in embryonic stem cells Yang, BX, El Farran, CA, Guo, HC, Yu, T, Fang, HT, Wang, HF, Schlesinger, S, Seah, YF, Goh, GY, Neo, SP, Li, Y, Lorincz, MC, Tergaonkar, V, Lim, TM, Chen, L, Gunaratne, J, Collins, JJ, Goff, SP, Daley, GQ, Li, H, Bard, FA, Loh, YH	Cell	2015
18082607	PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing Ivanov, AV, Peng, H, Yurchenko, V, Yap, KL, Negorev, DG, Schultz, DC, Psulkowski, E, Fredericks, WJ, White, DE, Maul, GG, Sadofsky, MJ, Zhou, MM, Rauscher FJ, 3rd	Mol Cell	2007