Npas4 binds NPAS4 gene

Stable Identifier
R-NUL-9769909
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Npas4 binds NPAS4 gene
A recombinant mouse Npas4 overexpressed in human embryonic kidney cell line HEK293T binds strongly to three enhancer elements in the human NPAS4 gene locus and weakly to the human NPAS4 gene promoter. The complex of recombinant mouse Npas4 and Arnt2 was able to significantly induce transcription from a human NPAS4 gene reporter construct (Bersten et al. 2014). High-throughput ChIP-seq of primary mouse neurons showed NPAS4 binds to the Npas4 gene locus (Kim et al. 2010). The heterodimer of Npas4 and Arnt2 is annotated as a set member and heterodimers of Npas4 with Arnt and Arntl are annotated as set candidates for binding to the Npas4 gene locus.
Literature References
PubMed ID Title Journal Year
20393465 Widespread transcription at neuronal activity-regulated enhancers

Kim, TK, Hemberg, M, Gray, JM, Costa, AM, Bear, DM, Wu, J, Harmin, DA, Laptewicz, M, Barbara-Haley, K, Kuersten, S, Markenscoff-Papadimitriou, E, Kuhl, D, Bito, H, Worley, PF, Kreiman, G, Greenberg, ME

Nature 2010
24291638 Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

Bersten, DC, Wright, JA, McCarthy, PJ, Whitelaw, ML

Biochim Biophys Acta 2014
Participants
Input
Output
Orthologous Events
NPAS4 binds NPAS4 gene enhancer elements (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-22)
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