Trim63 gene expression is stimulated by FOXO1, FOXO3 and SMAD3

Stable Identifier
R-NUL-9625772
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trim63 gene expression is stimulated by FOXO1, FOXO3 and SMAD3
Transcription of the mouse Trim63 is directly stimulated by a synergistic action of recombinant human FOXO1 and FOXO3 with recombinant human SMAD3 (Bollinger et al. 2014).
Literature References
PubMed ID Title Journal Year
24920680 SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner

Bollinger, LM, Witczak, CA, Houmard, JA, Brault, JJ

Am. J. Physiol., Cell Physiol. 2014
Participants
Input
Output
This event is regulated
Positively by
Regulator
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:Trim63 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1,FOXO3 [nucleoplasm]
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:Trim63 gene [nucleoplasm]
Orthologous Events
TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-22)
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