TRIM63 gene expression is stimulated by FOXO1 and FOXO3

Stable Identifier
R-HSA-9625693
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TRIM63 gene expression is stimulated by FOXO1 and FOXO3
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FOXO1 and activated glucocorticoid receptor (NR3C1) directly activate transcription of the TRIM63 gene, acting synergistically. TRIM63 (MuRF1) is an E3 ubiquitin ligase involved in degradation of muscle proteins and muscle atrophy during starvation, similar to FBXO31 (atrogin-1) (Waddell et al. 2008).
FOXO1 and FOXO3 directly activate TRIM63 gene transcription acting synergistically with SMAD3 (Bollinger et al. 2014, Wang et al. 2017). SMAD3 in the nucleus exist as a heterotrimer composed of two molecules of SMAD2 or SMAD3 and one molecule of SMAD4.
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] (Homo sapiens)
Active Unit
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
FOXO1 [nucleoplasm]
Regulator
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:TRIM63 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1,FOXO3 [nucleoplasm]
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
Inferred From
Trim63 gene expression is stimulated by FOXO1, FOXO3 and SMAD3 (Homo sapiens)
Trim63 gene expression is activated by Foxo1 and Nr3c1 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-22)
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