AMPK phosphorylates Mapt

Stable Identifier
R-NUL-9619534
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
AMPK phosphorylates Mapt

Recombinant rat AMPK complex, composed of AMPK-alpha1 (Prkaa1), AMPK-beta1 (Prkab1) and AMPK-gamma1 (Prkag1), phosphorylates recombinant human Tau protein on serine residues S262, S356 and S396 (Thornton et al. 2011, Mairet-Coello et al. 2013).

Literature References
PubMed ID Title Journal Year
21204788 AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Thornton, C, Bright, NJ, Sastre, M, Muckett, PJ, Carling, D

Biochem. J. 2011
23583109 The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

Mairet-Coello, G, Courchet, J, Pieraut, S, Courchet, V, Maximov, A, Polleux, F

Neuron 2013
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T183-AMPKalpha1beta1gamma1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created