AMPK phosphorylates MAPT

Stable Identifier
R-HSA-9619515
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AMPK, activated by CAMKK2-mediated phosphorylation, phosphorylates MAPT (Tau) on serine residues S262, S356 and S396. AMPK-mediated phosphorylation changes microtubule binding properties of MAPT and is involved in development and maintenance of dendritic spines and synaptotoxicity of beta-amyloid oligomers (Thornton et al. 2011, Mairet-Coello et al. 2013).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AMPK heterotrimer [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created