AMPK phosphorylates MAPT

Stable Identifier
R-HSA-9619515
Type
Reaction
Species
Homo sapiens
Compartment
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AMPK, activated by CAMKK2-mediated phosphorylation, phosphorylates MAPT (Tau) on serine residues S262, S356 and S396. AMPK-mediated phosphorylation changes microtubule binding properties of MAPT and is involved in development and maintenance of dendritic spines and synaptotoxicity of beta-amyloid oligomers (Thornton et al. 2011, Mairet-Coello et al. 2013).

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Participates
Catalyst Activity

protein serine/threonine kinase activity of p-AMPK heterotrimer [cytosol]

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