BAX activation is stimulated by Ntrk3(496-641) and Nelfb

Stable Identifier
R-NUL-9603625
Type
Reaction [omitted]
Species
Chlorocebus sabaeus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BAX activation is stimulated by Ntrk3(496-641) and Nelfb
The complex of recombinant mouse Ntrk3 (TrkC) killer fragment (KF) and recombinant mouse Nelfb (Cobra1) stimulates BAX activation in COS-7 cell line, derived from African green monkey kidneys, through an unknown mechanism. This is followed by BAX-dependent cytochrome C release and apoptosome-dependent cell death (Ichim et al. 2013).
Literature References
PubMed ID Title Journal Year
24034695 The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment

Ichim, G, Genevois, AL, Ménard, M, Yu, LY, Coelho-Aguiar, JM, Llambi, F, Jarrosson-Wuilleme, L, Lefebvre, J, Tulasne, D, Dupin, E, Le Douarin, N, Arumäe, U, Tauszig-Delamasure, S, Mehlen, P

Mol. Cell 2013
Participants
Input
Output
This event is regulated
Positively by
Regulator
Ntrk3(496-641):Nelfb [mitochondrial outer membrane] (Mus musculus)
Orthologous Events
BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-22)
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