Proteasome degrades SAX-3 ubiquitinated by EBAX-1

Stable Identifier
R-NUL-9011324
Type
Reaction [omitted]
Species
Caenorhabditis elegans
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Proteasome degrades SAX-3 ubiquitinated by EBAX-1
Human proteasome degrades recombinant C. elegans SAX-3 (orthologue of ROBO3.1) ubiquitinated by recombinant C. elegans EBAX-1 (orthologue of ZSWIM8), expressed in human embryonic kidney cell line 293T (Wang et al. 2013).
Literature References
PubMed ID Title Journal Year
24012004 The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons

Guo, X, Jin, Y, Boxem, M, Hou, Y, Wang, Z, van der Voet, M, Dixon, JE, Chisholm, AD

Neuron 2013
Participants
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
Authored
Reviewed
Created
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