Reactome | Proteasome degrades SAX-3 ubiquitinated by EBAX-1

Proteasome degrades SAX-3 ubiquitinated by EBAX-1

Stable Identifier

R-NUL-9011324

Type

Reaction [omitted]

Species

Caenorhabditis elegans

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

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Proteasome degrades SAX-3 ubiquitinated by EBAX-1

Human proteasome degrades recombinant C. elegans SAX-3 (orthologue of ROBO3.1) ubiquitinated by recombinant C. elegans EBAX-1 (orthologue of ZSWIM8), expressed in human embryonic kidney cell line 293T (Wang et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
24012004	The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons Wang, Z, Hou, Y, Guo, X, van der Voet, M, Boxem, M, Dixon, JE, Chisholm, AD, Jin, Y	Neuron	2013