Proteasome degrades ubiquitinated ROBO3.1

Stable Identifier
R-HSA-9011313
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies using recombinant C. elegans proteins expressed in human 293T cells, ZSWIM8-mediated ubiquitination of ROBO3.1 targets ROBO3.1 for proteasome-mediated degradation (Wang et al. 2013).

Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!