mouse Disp2 binds SHH N-terminal fragment

Stable Identifier
R-NUL-5362406
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
mouse Disp2 binds SHH N-terminal fragment
Mouse Disp2 binds to human SHH as assessed by co-immunoprecipitation after in vivo crosslinking in intact cells. Disp2 binds to the cholesterol moiety on SHH through its first extracellular loop and disruption of the interaction abrogates long range but not short range Hh signaling (Tukachinsky et al, 2012; Creanga et al, 2012)
Literature References
PubMed ID Title Journal Year
22902404 Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand

Jao, CY, Liu, J, Kuzmickas, RP, Salic, A, Tukachinsky, H

Cell Rep 2012
22677548 Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

Beachy, PA, Talbot, WS, Saunders, AM, Mann, RK, Glenn, TD, Creanga, A

Genes Dev. 2012
Participants
Input
Output
Orthologous Events
Hh-Np binds to DISP2 (Homo sapiens)
Authored
Rothfels, K  (2014-04-08)
Reviewed
Liu, Y C  (2014-05-16)
Created
Rothfels, K  (2014-04-16)
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