PKG1a phosphorylates BK channels

Stable Identifier
R-NUL-427888
Type
Reaction [transition]
Species
Bos taurus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PKG1a phosphorylates BK channels
NO-induced activation of cGMP-dependent protein kinase (PKG) increases the open probability of large conductance Ca2+-activated K+ channels (BK channels) by direct phosphorylation.
Literature References
PubMed ID Title Journal Year
10196172 Cyclic GMP-dependent protein kinase activates cloned BKCa channels expressed in mammalian cells by direct phosphorylation at serine 1072

Fukao, M, Mason, HS, Britton, FC, Kenyon, JL, Horowitz, B, Keef, KD

J Biol Chem 1999
Participants
Input
Output
Catalyst Activity

cGMP-dependent protein kinase activity of cGMP-dependent protein kinase 1, alpha isozyme [cytosol]

Physical Entity
cGMP-dependent protein kinase 1, alpha isozyme [cytosol] (Bos taurus)
Activity
cGMP-dependent protein kinase activity (GO:0004692)
Orthologous Events
PKG1 phosphorylates BK channels (Homo sapiens)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-06-29)
Cite Us!