Dissociation of beta-2 adrenergic receptor:Gs complex

Stable Identifier
R-NUL-421961
Type
Reaction [dissociation]
Species
Oryctolagus cuniculus
Compartment
General
SVG |   | PPTX  | SBGN
Dissociation of beta-2 adrenergic receptor:Gs complex

The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).

Literature References
PubMed ID Title Journal Year
3141418 Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes

Ransnäs, LA, Insel, PA

J Biol Chem 1988
Participants
Orthologous Events
Cross References
Target Pathogen
Authored
Reviewed
Created
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