ROCK1 phosphorylates LIMK2 (rat)

Stable Identifier
R-NUL-421733
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
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ROCK1 phosphorylates LIMK2 (rat)
ROCK-mediated phosphorylation of LIM kinase 2 at threonine residue T505 was demonstrated in experiments that used recombinant rat Limk2 and recombinant human ROCK2 ( Sumi et al. 2001).
Literature References
PubMed ID Title Journal Year
11018042 Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

Sumi, T, Matsumoto, K, Nakamura, T

J Biol Chem 2001
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of ROCK1 [cytosol]

Physical Entity
ROCK1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
LIM kinase phosphorylation by ROCK (Homo sapiens)
ROCK phosphorylates LIMK1,2 (Homo sapiens)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Rivero Crespo, F  (2014-12-26)
Created
Jupe, S  (2009-05-20)
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