ROCK phosphorylates LIMK1,2

Stable Identifier
R-HSA-3928577
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Rho-associated kinases (ROCKs) contribute to the formation of actin filaments by inactivating cofilin via phosphorylation of LIM domain kinases (LIMKs). ROCKs phosphorylate LIMK1 at Thr508 and LIMK2 at Thr505, enhancing the ability of LIMKs to phosphorylate cofilin. LIMK1 has been shown to be involved in dendritic spine development, as LIMK1 KO mice fail to form morphologically mature dendritic spines (Meng et al. 2002).

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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
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Activity
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Created