Neogenin binds repulsive guidance molecules

Stable Identifier
R-NUL-421689
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Neogenin binds repulsive guidance molecules
Among netrin1 receptors neogenin is the only protein to interact with the repulsive guidance molecules (RGM). RGMs are membrane bound proteins involved in axon guidance in the visual system. Neogenin is the dependence receptor and cleaved by activated caspase-3 to trigger apoptotic cell death. RGM binding blocks the cleavage of neogenin so RGM functions as a cell survival factor.
Literature References
PubMed ID Title Journal Year
15258591 RGM and its receptor neogenin regulate neuronal survival

Monnier, PP, Tauszig-Delamasure, S, Strittmatter, SM, Mehlen, P, Mueller, BK, Matsunaga, E, Chédotal, A

Nat Cell Biol 2004
15610137 Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development

Matsunaga, E, Chédotal, A

Dev Growth Differ 2004
Participants
Input
Output
Orthologous Events
Neogenin binds repulsive guidance molecules (RGDs) (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-05-19)
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