Neogenin binds repulsive guidance molecules (RGDs)

Stable Identifier
R-HSA-374692
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SVG |   | PPTX  | SBGN
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Among netrin1 receptors neogenin is the only protein to interact with the repulsive guidance molecules (RGM). RGMs are membrane bound proteins involved in axon guidance in the visual system. Neogenin is the dependence receptor and cleaved by activated caspase-3 to trigger apoptotic cell death. RGM binding blocks the cleavage of neogenin so RGM functions as a cell survival factor.

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