SREBP2 (SREBF2) is retained in the endoplasmic reticulum by SCAP:INSIG2:oxysterol

Stable Identifier
R-NUL-2317528
Type
Reaction [omitted]
Species
Cricetulus griseus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
High
 | PPTX  | SBGN
SREBP2 (SREBF2) is retained in the endoplasmic reticulum by SCAP:INSIG2:oxysterol
INSIG binds oxysterols and the INSIG:oxysterol complex interacts with SCAP subunits of the SREBP2:SCAP (SREBF2:SCAP) complex (Adams et al. 2004, Radhakrishnan et al. 2007). This interaction retains the SREBP2:SCAP:INSIG:oxysterol complex in the endoplasmic reticulum. From this reaction it is inferred that SREBP1A (SREBF1A) and SREBP1C (SREBF1C) are retained similarly.
Literature References
PubMed ID Title Journal Year
17428920 Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

Ikeda, Y, Goldstein, JL, Kwon, HJ, Radhakrishnan, A, Brown, MS

Proc. Natl. Acad. Sci. U.S.A. 2007
15452130 Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

Brown, MS, Adams, CM, De Brabander, JK, Feramisco, JD, Reitz, J, Li, L, Goldstein, JL

J Biol Chem 2004
Participants
Input
Output
Orthologous Events
SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)
Authored
May, B  (2012-06-10)
Created
May, B  (2012-06-13)
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