SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum

Stable Identifier
R-HSA-2317531
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
SREBF1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum
ReviewStatus
5/5
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SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum
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INSIG binds oxysterols and the INSIG:oxysterol complex interacts with SCAP subunits of the SREBP1A/1C/2:SCAP (SREBF1A/1C/2:SCAP) complex. This interaction retains the SREBP1A/1C/2:SCAP:INSIG:oxysterol complex in the endoplasmic reticulum. The order of assembly of the SREBP1A/1C/2:SCAP:INSIG:oxysterol complex is unknown.
Participants
Input
Output
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as an event of
Inferred From
SREBP2 (SREBF2) is retained in the endoplasmic reticulum by SCAP:INSIG2:oxysterol (Cricetulus griseus)
Authored
May, B  (2012-06-10)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2012-06-13)
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