Smad7:SMURF1 complex translocates to the cytosol

Stable Identifier
R-NUL-2169016
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
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PNG
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Smad7:SMURF1 complex translocates to the cytosol
XPO1 (CRM1) bound to Smad7:SMURF1 complex enables translocation of Smad1:SMURF1 to the cytosol. In this study, recombinant human SMURF1, recombinant mouse Smad7 and recombinant XPO1 (species not specified, assumed to be human) were exogenously expressed in COS7 cells (Tajima et al. 2003).
Literature References
PubMed ID Title Journal Year
12519765 Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

Tajima, Y, Goto, K, Yoshida, M, Shinomiya, K, Sekimoto, T, Yoneda, Y, Miyazono, K, Imamura, T

J Biol Chem 2003
Participants
Input
Output
Catalyst Activity

nuclear export signal receptor activity of Smad7:SMURF1:XPO1 [nucleoplasm]

Physical Entity
Smad7:SMURF1:XPO1 [nucleoplasm] (Homo sapiens)
Activity
nuclear export signal receptor activity (GO:0005049)
Orthologous Events
SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-27)
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