FBXW7 binds phosphorylated NICD1

Stable Identifier
R-NUL-2064853
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FBXW7 binds phosphorylated NICD1
The E3 ubiquitin ligase FBXW7, a homologue of C. elegans sel-10, binds to Notch1 intracellular domain NICD1. This interaction was demonstrated by co-immunoprecipitation of the human recombinant FBXW7 and mouse recombinant NICD1 (Oberg et al. 2001). FBXW7 binds phosphorylated intracellular domain of Notch proteins, as shown for mouse NICD1 (Fryer et al. 2004) and mouse NICD4 (Wu et al. 2001).
Literature References
PubMed ID Title Journal Year
11461910 The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

Lendahl, U, Li, J, Wolf, E, Pauley, A, Oberg, C, Gurney, M

J Biol Chem 2001
11585921 SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Das, I, Wu, G, Deshaies, RJ, Kitajewski, J, Li, J, Pauley, A, Chui, I, Gurney, M, Lyapina, S

Mol Cell Biol 2001
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, Jones, KA, White, JB

Mol Cell 2004
Participants
Input
Output
Orthologous Events
Phosphorylated NICD1 binds FBXW7 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-19)
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