Reactome | ADAM17 cleaves Notch1 at S2

ADAM17 cleaves Notch1 at S2

Stable Identifier

R-NUL-2063915

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

By expressing membrane bound mouse Notch1 construct NdeltaE lacking amino acids 21-1703, it was shown that the cleavage at the S2 site precedes cleavage at the S3 site performed by the gamma-secretase complex. Human ADAM17 isolated from HeLa cells was found to be capable of cleaving NdeltaE at S2.

Literature References

PubMed ID	Title	Journal	Year
10882063	A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE Brou, C, Logeat, F, Gupta, N, Bessia, C, LeBail, O, Doedens, JR, Cumano, A, Roux, P, Black, RA, Israel, A	Mol Cell	2000