ADAM17 cleaves Notch1 at S2

Stable Identifier
R-NUL-2063915
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
ADAM17 cleaves Notch1 at S2

By expressing membrane bound mouse Notch1 construct NdeltaE lacking amino acids 21-1703, it was shown that the cleavage at the S2 site precedes cleavage at the S3 site performed by the gamma-secretase complex. Human ADAM17 isolated from HeLa cells was found to be capable of cleaving NdeltaE at S2.

Literature References
PubMed ID Title Journal Year
10882063 A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

Brou, C, Logeat, F, Gupta, N, Bessia, C, LeBail, O, Doedens, JR, Cumano, A, Roux, P, Black, RA, Israel, A

Mol Cell 2000
Participants
Catalyst Activity

metalloendopeptidase activity of ADAM17 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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