ANPEP hydrolyzes Angiotensin III to Angiotensin IV

Stable Identifier
R-NUL-2022369
Type
Reaction [transition]
Species
Oryctolagus cuniculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ANPEP hydrolyzes Angiotensin III to Angiotensin IV
ANPEP from rabbit renal membranes hydrolyzes angiotensin III to yield angiotensin IV.
Literature References
PubMed ID Title Journal Year
1978675 Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M

Ward, PE, Benter, IF, Dick, L, Wilk, S

Biochem Pharmacol 1990
Participants
Input
Output
Catalyst Activity

metallopeptidase activity of ANPEP [plasma membrane]

Physical Entity
ANPEP [plasma membrane] (Oryctolagus cuniculus)
Activity
metallopeptidase activity (GO:0008237)
Orthologous Events
ANPEP:Zn2+ hydrolyzes AGT(26-32) (Angiotensin-(2-8)) to AGT(27-32) (Angiotensin-(3-8)) (Homo sapiens)
Authored
May, B  (2011-11-29)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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