ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)

Stable Identifier
R-HSA-2022393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ANPEP Hydrolyzes Angiotensin III to Yield Angiotensin IV
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Aminopeptidase N (APN, ANPEP, aminopeptidase M, alanyl aminopeptidase) hydrolyzes angiotensin-(2-8) (angiotensin III) to yield angiotensin-(3-8) (angiotensin IV) (see the positive control reactions in Diaz-Perales et al. 2005). Aminopeptidase O (AOPEP) also hydrolyzes angiotensin-(2-8) to angiotensin-(3-8) in vitro (Diaz-Perales et al. 2005) but AOPEP is located in the nucleolus in vivo (Axton et al. 2008) and angiotensin-(2-8) has not been observed in the nucleus.

Literature References
PubMed ID Title Journal Year
15687497 Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase

Díaz-Perales, A, Quesada, V, Sánchez, LM, Ugalde, AP, Suárez, MF, Fueyo, A, López-Otin, C

J Biol Chem 2005
17803194 Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology

Axton, R, Wallis, JA, Taylor, H, Hanks, M, Forrester, LM

J Cell Biochem 2008
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Catalyst Activity
Title
metallopeptidase activity of ANPEP Dimer [plasma membrane]
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