ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)

Stable Identifier
R-HSA-2022393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
ANPEP:Zn2+ Hydrolyzes Angiotensin III to Yield Angiotensin IV
ReviewStatus
5/5
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ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Aminopeptidase N (APN, ANPEP, aminopeptidase M, alanyl aminopeptidase) hydrolyzes angiotensin-(2-8) (angiotensin III) to yield angiotensin-(3-8) (angiotensin IV) (inferred from the rabbit homolog).
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Output
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as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

metallopeptidase activity of ANPEP:Zn2+ dimer [plasma membrane]

Physical Entity
ANPEP:Zn2+ dimer [plasma membrane] (Homo sapiens)
Activity
metallopeptidase activity (GO:0008237)
Inferred From
ANPEP hydrolyzes Angiotensin III to Angiotensin IV (Oryctolagus cuniculus)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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