frog CK1gamma phosphorylates LRP5/6

Stable Identifier
R-NUL-1458902
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
High
 | PPTX  | SBGN
frog CK1gamma phosphorylates LRP5/6
Xenopus tropicalis Casein kinase 1 gamma was identified in a screen for proteins that covalently modify LRP6. CK1gamma was shown to phosphorylate LRP6 in vitro and in vivo. This phosphorylation is required for Axin recruitment and WNT signaling (Davidson et al, 2005).
Literature References
PubMed ID Title Journal Year
16341016 Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

Davidson, G, Wu, W, Shen, J, Bilic, J, Fenger, U, Stannek, P, Glinka, A, Niehrs, C

Nature 2005
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of CKIgamma [plasma membrane]

Physical Entity
CKIgamma [plasma membrane] (Xenopus tropicalis)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2011-07-23)
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