Pks5 transforms LFCA adenylate ester to mycocerosyl

Stable Identifier
R-MTU-9635452
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
Synonyms
2 LCFA:Pks5 + (S)-methylmalonyl-CoA + 2 NADPH + 3 H+ => 2 mycocerosyl:Pks5 + CoA-SH + H2O + CO2 + 2 NADP+
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Pks5 transforms LFCA adenylate ester to mycocerosyl
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Mtb Pks5 (a mas homolog) synthesizes multimethylated mycocerosic acids. This protein acts on long-chain fatty acids adenylate esters (LCFA adenylate esters) in the LCFA adenylate ester:Pks5 complex by incorporating methylmalonyl residues, to form tri- or tetra-methylated branched fatty acids (mycocerosyl) (Roussau et al. 2003; Trivedi et al. 2005).

Literature References
PubMed ID Title Journal Year
15749014 Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid

Trivedi, OA, Arora, P, Vats, A, Ansari, MZ, Tickoo, R, Sridharan, V, Mohanty, D, Gokhale, RS

Mol. Cell 2005
12855735 Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis

Rousseau, C, Sirakova, TD, Dubey, VS, Bordat, Y, Kolattukudy, PE, Gicquel, B, Jackson, M

Microbiology (Reading, Engl.) 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
mycocerosate synthase activity of Pks5:LCFA adenylate ester [cytosol]
Physical Entity
Pks5:LCFA adenylate ester [cytosol]
Activity
mycocerosate synthase activity (0050111)
Authored
Pardo, AM  (2019-02-13)
Koile, I  (2019-02-13)
Reviewed
Stephan, R  (2019-02-13)
Created
Pardo, AM  (2019-02-05)
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