Pks5 transforms LFCA adenylate ester to mycocerosyl

Stable Identifier
R-MTU-9635452
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
Synonyms
2 LCFA:Pks5 + (S)-methylmalonyl-CoA + 2 NADPH + 3 H+ => 2 mycocerosyl:Pks5 + CoA-SH + H2O + CO2 + 2 NADP+
ReviewStatus
5/5
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Pks5 transforms LFCA adenylate ester to mycocerosyl
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Mtb Pks5 (a mas homolog) synthesizes multimethylated mycocerosic acids. This protein acts on long-chain fatty acids adenylate esters (LCFA adenylate esters) in the LCFA adenylate ester:Pks5 complex by incorporating methylmalonyl residues, to form tri- or tetra-methylated branched fatty acids (mycocerosyl) (Roussau et al. 2003; Trivedi et al. 2005).
Literature References
PubMed ID Title Journal Year
12855735 Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis

Gicquel, B, Kolattukudy, PE, Rousseau, C, Sirakova, TD, Jackson, M, Bordat, Y, Dubey, VS

Microbiology (Reading, Engl.) 2003
15749014 Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid

Ansari, MZ, Arora, P, Gokhale, RS, Mohanty, D, Tickoo, R, Vats, A, Sridharan, V, Trivedi, OA

Mol. Cell 2005
Participants
Input
Output
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as an event of
Catalyst Activity

mycocerosate synthase activity of Pks5:LCFA adenylate ester [cytosol]

Physical Entity
Pks5:LCFA adenylate ester [cytosol] (Mycobacterium tuberculosis)
Activity
mycocerosate synthase activity (GO:0050111)
Authored
Pardo, AM  (2019-02-13)
Koile, I  (2019-02-13)
Reviewed
Stephan, R  (2019-02-13)
Created
Pardo, AM  (2019-02-05)
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